Abiraterone acetate is used to treat metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (nmCSPC) in adult men. It works by inhibiting the production of the CYP17 enzyme. No production of this enzyme results in no production of male hormones, which fuels the cancer cell growth. As a result, the cancer cell cycle is interrupted and tumor growth halts.
Common side effects are fatigue, joint pain, high blood pressure, low potassium levels, hot flashes, and elevated liver enzymes. Serious side effects are adrenal insufficiency, cardiac disorders, and severe liver toxicity.